Small molecule control of pre-mRNA splicing.

  title={Small molecule control of pre-mRNA splicing.},
  author={Brenton R Graveley},
  volume={11 3},
SR proteins regulate alternative splicing by binding to exonic sequences where, via an arginine/serine-rich splicing activation domain, they enhance the binding of the spliceosome to the adjacent splice sites. Here, a system is described in which a nontoxic derivative of the small molecule rapamycin is used to control pre-mRNA splicing in vitro. This… CONTINUE READING