Small molecule analysis using laser desorption/ionization mass spectrometry on nano-coated silicon with self-assembled monolayers.

Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) is an emerging technique for the determination of the molecular weight of biomolecules and their non-covalent complexes without fragmentation. One problem with this technique is the use of excess amounts of matrices, which may produce intense fragment ions and/or clusters at low mass… (More)