Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

@article{Howitz2003SmallMA,
  title={Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan},
  author={K. Howitz and Kevin J. Bitterman and H. Cohen and D. Lamming and Siva Lavu and J. G. Wood and R. Zipkin and Phuong Chung and A. Kisielewski and L. Zhang and Brandy Scherer and D. Sinclair},
  journal={Nature},
  year={2003},
  volume={425},
  pages={191-196}
}
  • K. Howitz, Kevin J. Bitterman, +9 authors D. Sinclair
  • Published 2003
  • Medicine, Biology
  • Nature
  • In diverse organisms, calorie restriction slows the pace of ageing and increases maximum lifespan. In the budding yeast Saccharomyces cerevisiae, calorie restriction extends lifespan by increasing the activity of Sir2 (ref. 1), a member of the conserved sirtuin family of NAD+-dependent protein deacetylases. Included in this family are SIR-2.1, a Caenorhabditis elegans enzyme that regulates lifespan, and SIRT1, a human deacetylase that promotes cell survival by negatively regulating the p53… CONTINUE READING
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    References

    SHOWING 1-10 OF 75 REFERENCES
    Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
    • 1,767
    • PDF
    The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases.
    • 854
    • PDF
    Metabolic Control and Gene Dysregulation in Yeast Aging
    • S. Jazwinski
    • Biology, Medicine
    • Annals of the New York Academy of Sciences
    • 2000
    • 42
    • PDF
    A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family.
    • 680
    • PDF
    Paradigms and pitfalls of yeast longevity research
    • D. Sinclair
    • Biology, Medicine
    • Mechanisms of Ageing and Development
    • 2002
    • 80
    Human SIR2 deacetylates p53 and antagonizes PML/p53‐induced cellular senescence
    • 810
    • PDF