Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

  title={Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan},
  author={K. Howitz and Kevin J. Bitterman and H. Cohen and D. Lamming and Siva Lavu and J. G. Wood and R. Zipkin and Phuong Chung and A. Kisielewski and L. Zhang and Brandy Scherer and D. Sinclair},
  • K. Howitz, Kevin J. Bitterman, +9 authors D. Sinclair
  • Published 2003
  • Medicine, Biology
  • Nature
  • In diverse organisms, calorie restriction slows the pace of ageing and increases maximum lifespan. In the budding yeast Saccharomyces cerevisiae, calorie restriction extends lifespan by increasing the activity of Sir2 (ref. 1), a member of the conserved sirtuin family of NAD+-dependent protein deacetylases. Included in this family are SIR-2.1, a Caenorhabditis elegans enzyme that regulates lifespan, and SIRT1, a human deacetylase that promotes cell survival by negatively regulating the p53… CONTINUE READING
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