Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

@article{Howitz2003SmallMA,
  title={Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan},
  author={Konrad T. Howitz and Kevin J. Bitterman and Haim Y Cohen and Dudley Lamming and Siva Lavu and Jason G. Wood and Robert E. Zipkin and Phuong Chung and Anne Kisielewski and Li-li Zhang and Brandy Scherer and David A. Sinclair},
  journal={Nature},
  year={2003},
  volume={425},
  pages={191-196}
}
In diverse organisms, calorie restriction slows the pace of ageing and increases maximum lifespan. In the budding yeast Saccharomyces cerevisiae, calorie restriction extends lifespan by increasing the activity of Sir2 (ref. 1), a member of the conserved sirtuin family of NAD+-dependent protein deacetylases. Included in this family are SIR-2.1, a Caenorhabditis elegans enzyme that regulates lifespan, and SIRT1, a human deacetylase that promotes cell survival by negatively regulating the p53… 
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