Small-molecule activator of glutamate transporter EAAT2 translation provides neuroprotection.

Abstract

Glial glutamate transporter EAAT2 plays a major role in glutamate clearance in synaptic clefts. Several lines of evidence indicate that strategies designed to increase EAAT2 expression have potential for preventing excitotoxicity, which contributes to neuronal injury and death in neurodegenerative diseases. We previously discovered several classes of… (More)
DOI: 10.1172/JCI66163

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