Small molecule Toll-like receptor 7 agonists localize to the MHC class II loading compartment of human plasmacytoid dendritic cells.

@article{Russo2011SmallMT,
  title={Small molecule Toll-like receptor 7 agonists localize to the MHC class II loading compartment of human plasmacytoid dendritic cells.},
  author={Carla Russo and I. Cornella-Taracido and L. Galli-Stampino and R. Jain and Edmund M. Harrington and Y. Isome and Simona Tavarini and Chiara Sammicheli and S. Nuti and M. Mbow and N. Valiante and J. Tallarico and E. De Gregorio and E. Soldaini},
  journal={Blood},
  year={2011},
  volume={117 21},
  pages={
          5683-91
        }
}
TLR7 and TLR8 are intracellular sensors activated by single-stranded RNA species generated during viral infections. Various synthetic small molecules can also activate TLR7 or TLR8 or both through an unknown mechanism. Notably, direct interaction between small molecules and TLR7 or TLR8 has never been shown. To shed light on how small molecule agonists target TLRs, we labeled 2 imidazoquinolines, resiquimod and imiquimod, and one adenine-based compound, SM360320, with 2 different fluorophores… Expand
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  • Agnese Donadei, C. Balocchi, +7 authors R. Adamo
  • Chemistry, Medicine
  • European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
  • 2016
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