Small-molecule MDM2 antagonists attenuate the senescence-associated secretory phenotype

@inproceedings{Wiley2018SmallmoleculeMA,
  title={Small-molecule MDM2 antagonists attenuate the senescence-associated secretory phenotype},
  author={Christopher D. Wiley and Nicholas Schaum and Fatouma Alimirah and Jose Alberto Lopez-dominguez and Arturo V. Orjalo and G. Kellam Scott and P. Desprez and Christopher C. Benz and Albert R. Davalos and Judith Campisi},
  booktitle={Scientific Reports},
  year={2018}
}
Processes that have been linked to aging and cancer include an inflammatory milieu driven by senescent cells. Senescent cells lose the ability to divide, essentially irreversibly, and secrete numerous proteases, cytokines and growth factors, termed the senescence-associated secretory phenotype (SASP). Senescent cells that lack p53 tumor suppressor function show an exaggerated SASP, suggesting the SASP is negatively controlled by p53. Here, we show that increased p53 activity caused by small… CONTINUE READING
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