Small interfering RNAs mediate sequence-independent gene suppression and induce immune activation by signaling through toll-like receptor 3.

@article{Karik2004SmallIR,
  title={Small interfering RNAs mediate sequence-independent gene suppression and induce immune activation by signaling through toll-like receptor 3.},
  author={Katalin Karik{\'o} and Prakash Bhuyan and John Capodici and Drew Weissman},
  journal={Journal of immunology},
  year={2004},
  volume={172 11},
  pages={6545-9}
}
Small interfering (si) and short hairpin (sh) RNAs induce robust degradation of homologous mRNAs, making them a potent tool to achieve gene silencing in mammalian cells. Silencing by siRNAs is used widely because it is considered highly specific for the targeted gene, although a recent report suggests that siRNA also induce signaling through the type I IFN system. When human embryonic kidney 293 (HEK293) or keratinocyte (HaCaT) cell lines or human primary dendritic cells or macrophages were… CONTINUE READING
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