Small interfering RNAs against the TAR RNA binding protein, TRBP, a Dicer cofactor, inhibit human immunodeficiency virus type 1 long terminal repeat expression and viral production.

@article{Christensen2007SmallIR,
  title={Small interfering RNAs against the TAR RNA binding protein, TRBP, a Dicer cofactor, inhibit human immunodeficiency virus type 1 long terminal repeat expression and viral production.},
  author={Helen S Christensen and A{\"i}cha Daher and Kaitlin J. Soye and Lisa B Frankel and Marina R. Alexander and S{\'e}bastien Lain{\'e} and Sylvie Bannwarth and Chi L Ong and Sean W. L. Chung and Shahan M Campbell and Damian Purcell and Anne Gatignol},
  journal={Journal of virology},
  year={2007},
  volume={81 10},
  pages={5121-31}
}
RNA interference (RNAi) is now widely used for gene silencing in mammalian cells. The mechanism uses the RNA-induced silencing complex, in which Dicer, Ago2, and the human immunodeficiency virus type 1 (HIV-1) TAR RNA binding protein (TRBP) are the main components. TRBP is a protein that increases HIV-1 expression and replication by inhibition of the interferon-induced protein kinase PKR and by increasing translation of viral mRNA. After HIV infection, TRBP could restrict the viral RNA through… CONTINUE READING

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