Small interfering RNA therapy in cancer: mechanism, potential targets, and clinical applications.

@article{Huang2008SmallIR,
  title={Small interfering RNA therapy in cancer: mechanism, potential targets, and clinical applications.},
  author={Chuan Huang and Min Li and Changyi Johnny Chen and Q. -S. Yao},
  journal={Expert opinion on therapeutic targets},
  year={2008},
  volume={12 5},
  pages={637-45}
}
BACKGROUND Small interfering RNA (siRNA) has become a powerful tool in knocking down or silencing gene expression in most cells. siRNA-based therapy has shown great promise for many diseases such as cancer. Major targets for siRNA therapy include oncogenes and genes that are involved in angiogenesis, metastasis, survival, antiapoptosis and resistance to chemotherapy. OBJECTIVES This review briefly summarizes current advances in siRNA therapy and clinical applications in cancers, especially in… CONTINUE READING
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