Small interfering RNA profiling reveals key role of clathrin-mediated endocytosis and early endosome formation for infection by respiratory syncytial virus.

@article{Kolokoltsov2007SmallIR,
  title={Small interfering RNA profiling reveals key role of clathrin-mediated endocytosis and early endosome formation for infection by respiratory syncytial virus.},
  author={Andrey A. Kolokoltsov and Drew C. Deniger and Elisa H Fleming and Norbert J. Roberts and Jon M Karpilow and Robert A Davey},
  journal={Journal of virology},
  year={2007},
  volume={81 14},
  pages={7786-800}
}
Respiratory syncytial virus (RSV) is a common cause of respiratory tract infections in infants and the elderly. Like many other pH-independent enveloped viruses, RSV is thought to enter at the cell surface, independently of common endocytic pathways. We have used a targeted small interfering RNA (siRNA) library to identify key cellular genes involved in cytoskeletal dynamics and endosome trafficking that are important for RSV infection. Surprisingly, RSV infection was potently inhibited by… CONTINUE READING

Connections & Topics

Mentioned Connections BETA
Small interfering RNA profiling reveals key role of clathrin - mediated endocytosis and early endosome formation for infection by respiratory syncytial virus .
Small interfering RNA profiling reveals key role of clathrin - mediated endocytosis and early endosome formation for infection by respiratory syncytial virus .
Respiratory syncytial virus ( RSV ) is a common cause of respiratory tract infections in infants and the elderly .
Respiratory syncytial virus ( RSV ) is a common cause of respiratory tract infections in infants and the elderly .
Respiratory syncytial virus ( RSV ) is a common cause of respiratory tract infections in infants and the elderly .
Respiratory syncytial virus ( RSV ) is a common cause of respiratory tract infections in infants and the elderly .
We have used a targeted small interfering RNA ( siRNA ) library to identify key cellular genes involved in cytoskeletal dynamics and endosome trafficking that are important for RSV infection .
We have used a targeted small interfering RNA ( siRNA ) library to identify key cellular genes involved in cytoskeletal dynamics and endosome trafficking that are important for RSV infection .
All Topics