Small interfering RNA-mediated functional silencing of vasopressin V2 receptors in the mouse kidney.

@article{Hassan2005SmallIR,
  title={Small interfering RNA-mediated functional silencing of vasopressin V2 receptors in the mouse kidney.},
  author={Ali Mohammed Ali Hassan and Ying Tian and Wei Zheng and Hong Ji and Kathryn Sandberg and Joseph G. Verbalis},
  journal={Physiological genomics},
  year={2005},
  volume={21 3},
  pages={382-8}
}
The antidiuretic effects of arginine vasopressin (AVP) on the kidney are mediated by V2 subtype AVP receptors (V2R). To investigate the role of regulation of V2R in water and sodium homeostasis, we have developed a method for small interfering RNA (siRNA)-mediated inhibition of V2R expression in vivo. Three 21-nt siRNA sequences were chosen that specifically targeted the mouse V2R but shared no appreciable sequence homology to any other known mouse genes, including the vasopressin V1a and V1b… CONTINUE READING

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