Small interfering RNA for experimental cancer therapy.

  title={Small interfering RNA for experimental cancer therapy.},
  author={Alex W. Tong and Yu-an Zhang and John Nemunaitis},
  journal={Current opinion in molecular therapeutics},
  volume={7 2},
RNA interference describes the recently discovered process of sequence-specific, post-transcriptional gene silencing that is initiated by double-stranded RNA molecules known as small interfering RNAs (siRNAs). siRNAs have an acceptable half-life in vitro, a predictable biodistribution profile similar to that of single-stranded antisense oligonucleotides (ASOs), and have repeatedly been more robust than ASO techniques in terms of consistency of transcript knockdown and threshold concentration… CONTINUE READING


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