Small interfering RNA-directed targeting of Toll-like receptor 4 inhibits human prostate cancer cell invasion, survival, and tumorigenicity.

@article{Hua2009SmallIR,
  title={Small interfering RNA-directed targeting of Toll-like receptor 4 inhibits human prostate cancer cell invasion, survival, and tumorigenicity.},
  author={Dong Hua and Meng-yuan Liu and Zhi-de Cheng and Xiang-jing Qin and Hai-mou Zhang and Yong Chen and Gang-Jian Qin and Gang Liang and Ji-Nan Li and Xiao-Feng Han and Dong-xu Liu},
  journal={Molecular immunology},
  year={2009},
  volume={46 15},
  pages={2876-84}
}
A major cause of tumor treatment failure is cancer cell metastasis. Toll-like receptor 4 (TLR4)-mediated signaling has been implicated in tumor cell invasion, survival, and metastasis in a variety of cancers. In this study, we investigated the biological roles of TLR4 in prostate metastatic cell invasion and survival, and the potential of gene silencing of TLR4 using small interfering RNA (siRNA) for treatment of cancer. In cultured human prostate cancer cell lines, TLR4 were higher PC3 and… CONTINUE READING