Small interfering RNA delivery to the liver by intravenous administration of galactosylated cationic liposomes in mice.

@article{Sato2007SmallIR,
  title={Small interfering RNA delivery to the liver by intravenous administration of galactosylated cationic liposomes in mice.},
  author={Ayumi Sato and Motoki Takagi and Akira Shimamoto and Shigeru Kawakami and Mitsuru Hashida},
  journal={Biomaterials},
  year={2007},
  volume={28 7},
  pages={1434-42}
}
Although small interfering RNA (siRNA) is a potentially useful therapeutic approach to silence the targeted gene of a particular disease, its use is limited by its stability in vivo. For the liver parenchymal cell (PC)-selective delivery of siRNA, siRNA was complexed with galactosylated cationic liposomes. Galactosylated liposomes/siRNA complex exhibited a higher stability than naked siRNA in plasma. After intravenous administration of a galactosylated liposomes/siRNA complex, the siRNA did not… CONTINUE READING