Small increases in the level of Sox2 trigger the differentiation of mouse embryonic stem cells.


Previous studies have demonstrated that the transcription factor Sox2 is essential during the early stages of development. Furthermore, decreasing the expression of Sox2 severely interferes with the self-renewal and pluripotency of embryonic stem (ES) cells. Other studies have shown that Sox2, in conjunction with the transcription factor Oct-3/4, stimulates… (More)
DOI: 10.1634/stemcells.2007-0951


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