Small heterodimer partner interacts with NLRP3 and negatively regulates activation of the NLRP3 inflammasome

@inproceedings{Yang2015SmallHP,
  title={Small heterodimer partner interacts with NLRP3 and negatively regulates activation of the NLRP3 inflammasome},
  author={Chul-Su Yang and J Kim and Tae Sung Kim and Phil Young Lee and Soo Yeon Kim and H J Lee and Dong-Min Shin and Loi T. Nguyen and Moo-Seung Lee and Hyo Sun Jin and Kwang-Kyu Kim and Chul-Ho Lee and Myung Hee Kim and Sung Goo Park and Jin-man Kim and Hueng-Sik Choi and Eun Kyeong Jo},
  booktitle={Nature communications},
  year={2015}
}
Excessive activation of the NLRP3 inflammasome results in damaging inflammation, yet the regulators of this process remain poorly defined. Herein, we show that the orphan nuclear receptor small heterodimer partner (SHP) is a negative regulator of NLRP3 inflammasome activation. NLRP3 inflammasome activation leads to an interaction between SHP and NLRP3, proteins that are both recruited to mitochondria. Overexpression of SHP competitively inhibits binding of NLRP3 to apoptosis-associated speck… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 25 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 49 references

Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis

  • Vande, L W.
  • Nature 512,
  • 2014

is there a role for mitochondria? Biochim

  • Lawlor, K. E. et al. Ambiguities in NLRP3 inflammasome regulation
  • Biophys. Acta 1840, 1433–1440
  • 2014

Characterization of the mitochondrial localization of the nuclear receptor SHP and regulation of its subcellular distribution by interaction with Bcl2 and HNF4a

  • Y Zhang
  • PLoS ONE 8,
  • 2013

Negative regulation of NLRP3 inflammasome signaling

  • S Chen
  • Protein Cell 4,
  • 2013

Similar Papers

Loading similar papers…