Small heterodimer partner attenuates profibrogenic features of hepatitis C virus-infected cells.

@article{Jung2015SmallHP,
  title={Small heterodimer partner attenuates profibrogenic features of hepatitis C virus-infected cells.},
  author={Gwon Soo Jung and Jae-Han Jeon and Yeon-kyung Choi and Se Young Jang and Soo Young Park and Mi-Kyeong Kim and Eui-Cheol Shin and Won-il Jeong and In-Kyu Lee and Yu Na Kang and Keun Gyu Park},
  journal={Liver international : official journal of the International Association for the Study of the Liver},
  year={2015},
  volume={35 10},
  pages={2233-45}
}
BACKGROUND & AIMS An atypical orphan nuclear receptor small heterodimer partner (SHP) is known to be regulated by AMP-activated protein kinase (AMPK). Both of them inhibit TGF-β and Smad signalling and exhibit antifibrotic activity in the liver. However, little is known about the protective effects of SHP and AMPK against hepatitis c virus (HCV)-induced… CONTINUE READING