Small heat-shock proteins and their potential role in human disease.

  title={Small heat-shock proteins and their potential role in human disease.},
  author={John I Clark and Paul Joseph Muchowski},
  journal={Current opinion in structural biology},
  volume={10 1},
The elevated expression of stress proteins is considered to be a universal response to adverse conditions, representing a potential mechanism of cellular defense against disease and a potential target for novel therapeutics, including gene therapy and chaperone-modulating reagents. Recently, a single mutation in the small heat-shock protein human alphaB-crystallin was linked to desmin-related myopathy, which is characterized by abnormal intracellular aggregates of intermediate filaments in… CONTINUE READING

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