Small heat-shock proteins and clusterin: intra- and extracellular molecular chaperones with a common mechanism of action and function?

@article{Carver2003SmallHP,
  title={Small heat-shock proteins and clusterin: intra- and extracellular molecular chaperones with a common mechanism of action and function?},
  author={John A Carver and Agata Rekas and David C. Thorn and Mark R. Wilson},
  journal={IUBMB life},
  year={2003},
  volume={55 12},
  pages={661-8}
}
Small heat-shock proteins (sHsps) and clusterin are molecular chaperones that share many functional similarities despite their lack of significant sequence similarity. These functional similarities, and some differences, are discussed. sHsps are ubiquitous intracellular proteins whereas clusterin is generally found extracellularly. Both chaperones potently prevent the amorphous aggregation and precipitation of target proteins under stress conditions such as elevated temperature, reduction and… CONTINUE READING

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