Small heat shock proteins Hsp27 or alphaB-crystallin and the protein components of neurofibrillary tangles: tau and neurofilaments.

@article{Bjrkdahl2008SmallHS,
  title={Small heat shock proteins Hsp27 or alphaB-crystallin and the protein components of neurofibrillary tangles: tau and neurofilaments.},
  author={Cecilia Bj{\"o}rkdahl and Magnus J.C. Sj{\"o}gren and Xinwen Zhou and Hernan Q Concha and Jes{\'u}s {\'A}vila and Bengt Winblad and J F Pei},
  journal={Journal of neuroscience research},
  year={2008},
  volume={86 6},
  pages={1343-52}
}
The heat-shock proteins (HSPs) Hsp27 and alphaB-crystallin are up-regulated in Alzheimer's disease (AD), but the extent of this and the consequences are still largely unknown. The HSPs are involved in protein degradation and protection against protein aggregation, and they interact with several cytoskeletal components such as microtubules (MT) and neurofilaments (NF). AD pathology includes aggregated proteins (tau, NF), decreased protein degradation, and cytoskeletal disruption. It is thus of… CONTINUE READING
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