Small functional groups for controlled differentiation of hydrogel-encapsulated human mesenchymal stem cells.

@article{Benoit2008SmallFG,
  title={Small functional groups for controlled differentiation of hydrogel-encapsulated human mesenchymal stem cells.},
  author={Danielle S W Benoit and Michael P. Schwartz and Andrew R Durney and Kristi S Anseth},
  journal={Nature materials},
  year={2008},
  volume={7 10},
  pages={816-23}
}
Cell-matrix interactions have critical roles in regeneration, development and disease. The work presented here demonstrates that encapsulated human mesenchymal stem cells (hMSCs) can be induced to differentiate down osteogenic and adipogenic pathways by controlling their three-dimensional environment using tethered small-molecule chemical functional groups. Hydrogels were formed using sufficiently low concentrations of tether molecules to maintain constant physical characteristics… CONTINUE READING

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