Small fitness effects and weak genetic interactions between deleterious mutations in heterozygous loci of the yeast Saccharomyces cerevisiae.

@article{Szafraniec2003SmallFE,
  title={Small fitness effects and weak genetic interactions between deleterious mutations in heterozygous loci of the yeast Saccharomyces cerevisiae.},
  author={Krzysztof Szafraniec and Dominika M Wloch and Piotr Sliwa and Rhona H. Borts and Ryszard Korona},
  journal={Genetical research},
  year={2003},
  volume={82 1},
  pages={
          19-31
        }
}
Rare, random mutations were induced in budding yeast by ethyl methanesulfonate (EMS). Clones known to bear a single non-neutral mutation were used to obtain mutant heterozygotes and mutant homozygotes that were later compared with wild-type homozygotes. The average homozygous effect of mutation was an approximately 2% decrease in the growth rate. In heterozygotes, the harmful effect of these relatively mild mutations was reduced approximately fivefold. In a test of epistasis, two heterozygous… CONTINUE READING
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Epistatic interactions of spontaneous mutations in haploid

  • D. M. Wloch, R. H. Borts, R. Korona
  • 2001
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