Small-conductance, calcium-activated potassium channels from mammalian brain.

  title={Small-conductance, calcium-activated potassium channels from mammalian brain.},
  author={Michael K{\"o}hler and Birgit Hirschberg and Chris T. Bond and J M Kinzie and Neil V. Marrion and James Maylie and John P Adelman},
  volume={273 5282},
Members of a previously unidentified family of potassium channel subunits were cloned from rat and human brain. The messenger RNAs encoding these subunits were widely expressed in brain with distinct yet overlapping patterns, as well as in several peripheral tissues. Expression of the messenger RNAs in Xenopus oocytes resulted in calcium-activated, voltage-independent potassium channels. The channels that formed from the various subunits displayed differential sensitivity to apamin and… CONTINUE READING
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