Small-conductance, Ca2+-activated K+ channel SK3 generates age-related memory and LTP deficits

@article{Blank2003SmallconductanceCK,
  title={Small-conductance, Ca2+-activated K+ channel SK3 generates age-related memory and LTP deficits},
  author={Thomas E. Blank and Ingrid Nijholt and M Kye and Jelena Radulovic and Joachim Spiess},
  journal={Nature Neuroscience},
  year={2003},
  volume={6},
  pages={911-912}
}
Cognitive deficits are among the most devastating changes associated with the aging process. Age-related decrement in performance on learning tasks is correlated with substantial changes in neuronal signal processing in the hippocampus. Here we show that elevated expression of small-conductance Ca2+-activated K+ channels (SK channels) of the SK3 type in hippocampi of aged mice contributes to reduced long-term potentiation (LTP) and impaired trace fear conditioning, a hippocampus-dependent… CONTINUE READING