Small bristles, the Drosophila ortholog of NXF-1, is essential for mRNA export throughout development.

@article{Wilkie2001SmallBT,
  title={Small bristles, the Drosophila ortholog of NXF-1, is essential for mRNA export throughout development.},
  author={Gavin S. Wilkie and Vitaly Zimyanin and Ruth Kirby and Christopher A. Korey and Helen L Francis-Lang and David L Van Vactor and Ilan Davis},
  journal={RNA},
  year={2001},
  volume={7 12},
  pages={1781-92}
}
We identified a temperature-sensitive allele of small bristles (sbr), the Drosophila ortholog of human TAP/NXF-1 and yeast Mex67, in a screen for mutants defective in mRNA export. We show that sbr is essential for the nuclear export of all mRNAs tested in a wide range of tissues and times in development. High resolution and sensitive in situ hybridization detect the rapid accumulation of individual mRNA species in sbr mutant nuclei in particles that are distinct from nascent transcript foci and… CONTINUE READING
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