Small-bowel mucosal transglutaminase 2-specific IgA deposits in coeliac disease without villous atrophy: A prospective and randomized clinical study

@article{Kaukinen2005SmallbowelMT,
  title={Small-bowel mucosal transglutaminase 2-specific IgA deposits in coeliac disease without villous atrophy: A prospective and randomized clinical study},
  author={K. Kaukinen and M. Per{\"a}aho and P. Collin and J. Partanen and N. Woolley and T. Kaartinen and T. Nuutinen and T. Halttunen and M. M{\"a}ki and I. Korponay-Szab{\'o}},
  journal={Scandinavian Journal of Gastroenterology},
  year={2005},
  volume={40},
  pages={564 - 572}
}
  • K. Kaukinen, M. Peräaho, +7 authors I. Korponay-Szabó
  • Published 2005
  • Medicine
  • Scandinavian Journal of Gastroenterology
  • Objective In coeliac disease, autoantibodies directed against transglutaminase 2 are produced in small-bowel mucosa, and they have been found to be deposited extracellularly. The aim of this study was to investigate whether such mucosal IgA deposits are important in the diagnostic work-up of early-stage coeliac disease without small-bowel mucosal villous atrophy. Material and methods Forty-one adults suspected of coeliac disease owing to increased density of mucosal γδ+ intraepithelial… CONTINUE READING
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