Small-bowel mucosal transglutaminase 2-specific IgA deposits in coeliac disease without villous atrophy: A prospective and randomized clinical study

@article{Kaukinen2005SmallbowelMT,
  title={Small-bowel mucosal transglutaminase 2-specific IgA deposits in coeliac disease without villous atrophy: A prospective and randomized clinical study},
  author={Katri Kaukinen and Markku Per{\"a}aho and Pekka Collin and Jukka Partanen and Niina Woolley and Tanja Kaartinen and Tuula Nuutinen and Tuula Halttunen and Markku J M{\"a}ki and Ilma R. Korponay-Szab{\'o}},
  journal={Scandinavian Journal of Gastroenterology},
  year={2005},
  volume={40},
  pages={564 - 572}
}
Objective In coeliac disease, autoantibodies directed against transglutaminase 2 are produced in small-bowel mucosa, and they have been found to be deposited extracellularly. The aim of this study was to investigate whether such mucosal IgA deposits are important in the diagnostic work-up of early-stage coeliac disease without small-bowel mucosal villous atrophy. Material and methods Forty-one adults suspected of coeliac disease owing to increased density of mucosal γδ+ intraepithelial… Expand
Gluten-dependent Small Bowel Mucosal Transglutaminase 2–specific IgA Deposits in Overt and Mild Enteropathy Coeliac Disease
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The response of small bowel mucosal transglutaminase-2–specific IgA deposits for dietary intervention was similar in overt and mild enteropathy coeliac disease. Expand
Usefulness of Small-bowel Mucosal Transglutaminase-2 Specific Autoantibody Deposits in the Diagnosis and Follow-up of Celiac Disease
TLDR
Mucosal transglutaminase-2 specific mucosal IgA autoantibody deposits proved to be accurate gluten-dependent markers of celiac disease and would thus be of value in the diagnostics and dietary monitoring of this disorder. Expand
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  • O. Koskinen, K. Lindfors, +6 authors K. Kaukinen
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TLDR
Small-bowel mucosal autoantibody deposits were more accurate in detecting coeliac disease than serology or IEL densities, enabling the design of appropriate therapeutic strategies. Expand
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TLDR
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TLDR
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TLDR
In vivo effects of coeliac disease patient antibodies and especially TG2-targeted autoantibodies relevant to the pathogenesis of the disease are demonstrated and inhibited angiogenesis in vitro, ex vivo and in vivo. Expand
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