Small-bowel mucosal transglutaminase 2-specific IgA deposits in coeliac disease without villous atrophy: A prospective and randomized clinical study

@article{Kaukinen2005SmallbowelMT,
  title={Small-bowel mucosal transglutaminase 2-specific IgA deposits in coeliac disease without villous atrophy: A prospective and randomized clinical study},
  author={Katri Kaukinen and Markku Per{\"a}aho and Pekka Collin and Jukka Partanen and Niina Woolley and Tanja Kaartinen and Tuula Nuutinen and Tuula Halttunen and Markku J M{\"a}ki and Ilma R. Korponay-Szab{\'o}},
  journal={Scandinavian Journal of Gastroenterology},
  year={2005},
  volume={40},
  pages={564 - 572}
}
Objective In coeliac disease, autoantibodies directed against transglutaminase 2 are produced in small-bowel mucosa, and they have been found to be deposited extracellularly. The aim of this study was to investigate whether such mucosal IgA deposits are important in the diagnostic work-up of early-stage coeliac disease without small-bowel mucosal villous atrophy. Material and methods Forty-one adults suspected of coeliac disease owing to increased density of mucosal γδ+ intraepithelial… 

Gluten-dependent Small Bowel Mucosal Transglutaminase 2–specific IgA Deposits in Overt and Mild Enteropathy Coeliac Disease

The response of small bowel mucosal transglutaminase-2–specific IgA deposits for dietary intervention was similar in overt and mild enteropathy coeliac disease.

Usefulness of Small-bowel Mucosal Transglutaminase-2 Specific Autoantibody Deposits in the Diagnosis and Follow-up of Celiac Disease

Mucosal transglutaminase-2 specific mucosal IgA autoantibody deposits proved to be accurate gluten-dependent markers of celiac disease and would thus be of value in the diagnostics and dietary monitoring of this disorder.

Intestinal transglutaminase 2 specific antibody deposits in non-responsive coeliac disease.

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Pan-Gastrointestinal Tract Mucosal Pathologies in Patients with Celiac Disease with the Demonstration of IgA Anti-Transglutaminase Mucosal Deposits: A Case–Control Study

Significantly higher number of patients with CeD had evidence of lymphocytic infiltration and IgA anti-TG2 deposits along GIT suggesting that CeD affects other parts of GIT.

Immunoglobulin A Anti-tissue Transglutaminase Antibody Deposits in the Small Intestinal Mucosa of Children With No Villous Atrophy

A subgroup of children with no serum CD-associated autoantibodies, but greater density of γδ intraepithelial lymphocytes, shows a clear anti-TG2 IgA deposition in the duodenal mucosa, and must be investigated further for possible gluten sensitivity.

Altered small-bowel mucosal vascular network in untreated coeliac disease

On a gluten-containing diet the mucosal vasculature in the small intestine of untreated coeliac disease patients was altered in overall organization as well as in the number and maturity of the vessels when compared to healthy subjects.

Secretion of celiac disease autoantibodies after in vitro gliadin challenge is dependent on small-bowel mucosal transglutaminase 2-specific IgA deposits

Whether autoantibody secretion to organ culture supernatants in treated celiac disease patient biopsies is related to the duration of the diet and further to the pre-existence of mucosal TG2-specific IgA deposits in the cultured biopsy samples is established.

Small bowel transglutaminase 2-specific IgA deposits in dermatitis herpetiformis.

The majority of untreated DH patients have similar gluten-dependent TG2-specific IgA deposits the small bowel mucosa as coeliac disease patients, and the presence of the deposits showed a significant association with the degree of small bowel villous atrophy.

Small-intestinal TG2-specific plasma cells at different stages of coeliac disease

The results show that TG2-specific plasma cells are already detectable prior to villous atrophy, and that generally their frequency increases during overt disease, but the frequency is not always parallel to the level of serum or intestinal TG2 antibodies.

Biological effects of coeliac disease patient antibodies in vivo

In vivo effects of coeliac disease patient antibodies and especially TG2-targeted autoantibodies relevant to the pathogenesis of the disease are demonstrated and inhibited angiogenesis in vitro, ex vivo and in vivo.
...

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