Small-bowel mucosal transglutaminase 2-specific IgA deposits in coeliac disease without villous atrophy: A prospective and randomized clinical study

  title={Small-bowel mucosal transglutaminase 2-specific IgA deposits in coeliac disease without villous atrophy: A prospective and randomized clinical study},
  author={Katri Kaukinen and Markku Per{\"a}aho and Pekka Collin and Jukka Partanen and Niina Woolley and Tanja Kaartinen and Tuula Nuutinen and Tuula Halttunen and Markku J M{\"a}ki and Ilma R. Korponay-Szab{\'o}},
  journal={Scandinavian Journal of Gastroenterology},
  pages={564 - 572}
Objective In coeliac disease, autoantibodies directed against transglutaminase 2 are produced in small-bowel mucosa, and they have been found to be deposited extracellularly. The aim of this study was to investigate whether such mucosal IgA deposits are important in the diagnostic work-up of early-stage coeliac disease without small-bowel mucosal villous atrophy. Material and methods Forty-one adults suspected of coeliac disease owing to increased density of mucosal γδ+ intraepithelial… 

Gluten-dependent Small Bowel Mucosal Transglutaminase 2–specific IgA Deposits in Overt and Mild Enteropathy Coeliac Disease

The response of small bowel mucosal transglutaminase-2–specific IgA deposits for dietary intervention was similar in overt and mild enteropathy coeliac disease.

Usefulness of Small-bowel Mucosal Transglutaminase-2 Specific Autoantibody Deposits in the Diagnosis and Follow-up of Celiac Disease

Mucosal transglutaminase-2 specific mucosal IgA autoantibody deposits proved to be accurate gluten-dependent markers of celiac disease and would thus be of value in the diagnostics and dietary monitoring of this disorder.

Intestinal transglutaminase 2 specific antibody deposits in non-responsive coeliac disease.

  • O. KoskinenK. Lindfors K. Kaukinen
  • Medicine
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
  • 2010

Pan-Gastrointestinal Tract Mucosal Pathologies in Patients with Celiac Disease with the Demonstration of IgA Anti-Transglutaminase Mucosal Deposits: A Case–Control Study

Significantly higher number of patients with CeD had evidence of lymphocytic infiltration and IgA anti-TG2 deposits along GIT suggesting that CeD affects other parts of GIT.

Immunoglobulin A Anti-tissue Transglutaminase Antibody Deposits in the Small Intestinal Mucosa of Children With No Villous Atrophy

A subgroup of children with no serum CD-associated autoantibodies, but greater density of γδ intraepithelial lymphocytes, shows a clear anti-TG2 IgA deposition in the duodenal mucosa, and must be investigated further for possible gluten sensitivity.

Altered small-bowel mucosal vascular network in untreated coeliac disease

On a gluten-containing diet the mucosal vasculature in the small intestine of untreated coeliac disease patients was altered in overall organization as well as in the number and maturity of the vessels when compared to healthy subjects.

Secretion of celiac disease autoantibodies after in vitro gliadin challenge is dependent on small-bowel mucosal transglutaminase 2-specific IgA deposits

Whether autoantibody secretion to organ culture supernatants in treated celiac disease patient biopsies is related to the duration of the diet and further to the pre-existence of mucosal TG2-specific IgA deposits in the cultured biopsy samples is established.

Small bowel transglutaminase 2-specific IgA deposits in dermatitis herpetiformis.

The majority of untreated DH patients have similar gluten-dependent TG2-specific IgA deposits the small bowel mucosa as coeliac disease patients, and the presence of the deposits showed a significant association with the degree of small bowel villous atrophy.

Small-intestinal TG2-specific plasma cells at different stages of coeliac disease

The results show that TG2-specific plasma cells are already detectable prior to villous atrophy, and that generally their frequency increases during overt disease, but the frequency is not always parallel to the level of serum or intestinal TG2 antibodies.

Biological effects of coeliac disease patient antibodies in vivo

In vivo effects of coeliac disease patient antibodies and especially TG2-targeted autoantibodies relevant to the pathogenesis of the disease are demonstrated and inhibited angiogenesis in vitro, ex vivo and in vivo.



Small-bowel mucosal inflammation in reticulin or gliadin antibody-positive patients without villous atrophy.

GA-class antireticulin or antigliadin antibody-positive patients with normal small-bowel mucosal morphology frequently have immunohistochemical markers of coeliac disease latency, which implies that they may be gluten-sensitive.

In vivo targeting of intestinal and extraintestinal transglutaminase 2 by coeliac autoantibodies

Coeliac IgA targets jejunal TG2 early in disease development even when endomysial antibodies are not present in the circulation, indicating that humoral immunity may have a pathogenetic role.

Celiac Disease Without Villous Atrophy

The authors' patients showed a clinical, histological, and serological recovery on diet; risk of osteopenia speaks in favor of dietary treatment, and the inflammation resolved on gluten-free diet, and abdominal symptoms were alleviated.

Increased density of jejunal gammadelta+ T cells in patients having normal mucosa--marker of operative autoimmune mechanisms?

Evidence for mucosal markers of coeliac disease latency in patients clinically suspected but on routine biopsy excluded for the disease is found and reticulin autoantibody-positive children having normal jejunal mucosal morphology had significantly higher densities of intraepithelial gammadelta+ T cells than antibody negative ones.

Increased Density of Jejunal γδ+ T Cells in Patients Having Normal Mucosa - Marker of Operative Autoimmune Mechanisms?

The aim of the present study was to find evidence for mucosal markers of coeliac disease latency in patients clinically suspected but on routine biopsy excluded for the disease.

Intestinal antibody pattern of coeliac disease: association with gamma/delta T cell receptor expression by intraepithelial lymphocytes, and other indices of potential coeliac disease.

Clinical tests of gluten sensitivity will be required to establish the prevalence of latent gluten sensitive enteropathy in the 40% of patients referred for jejunal biopsy in whom one or more of the immunological indices of potential coeliac disease is present.

Celiac disease without villous atrophy: revision of criteria called for.

Ten adults suspected to have celiac disease but evincing only minor mucosal inflammation and increase in gammadelta+ cells without villous atrophy showed a clinical, histological, and serological recovery on diet; risk of osteopenia speaks in favor of dietary treatment.

Celiac disease-like abnormalities in a subgroup of patients with irritable bowel syndrome.

HLA-DQ2 expression and increased intestinal cd-associated antibodies are markers that can identify latent/potential cd in a subgroup of IBS patients who consequently appear to profit from a gluten-free diet.

Gluten-sensitive disease with mild enteropathy.

Gluten-sensitive celiac-like symptoms may occur in patients with serum antiendomysium antibodies, apparently normal intestinal mucosa, and HLA typing not commonly associated with celiac disease.