Small animal fluorescence and bioluminescence tomography: a review of approaches, algorithms and technology update

  title={Small animal fluorescence and bioluminescence tomography: a review of approaches, algorithms and technology update},
  author={Chinmay D. Darne and Yujie Lu and Eva M. Sevick-Muraca},
  journal={Physics in Medicine and Biology},
  pages={R1 - R64}
Emerging fluorescence and bioluminescence tomography approaches have several common, yet several distinct features from established emission tomographies of PET and SPECT. Although both nuclear and optical imaging modalities involve counting of photons, nuclear imaging techniques collect the emitted high energy (100–511 keV) photons after radioactive decay of radionuclides while optical techniques count low-energy (1.5–4.1 eV) photons that are scattered and absorbed by tissues requiring models… 

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