Small-animal SPECT/CT of HER2 and HER3 expression in tumor xenografts in athymic mice using trastuzumab Fab-heregulin bispecific radioimmunoconjugates.

@article{Razumienko2012SmallanimalSO,
  title={Small-animal SPECT/CT of HER2 and HER3 expression in tumor xenografts in athymic mice using trastuzumab Fab-heregulin bispecific radioimmunoconjugates.},
  author={Eva J Razumienko and Deborah A. Scollard and Raymond M Reilly},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year={2012},
  volume={53 12},
  pages={1943-50}
}
UNLABELLED Heterodimerization of human epidermal growth factor receptor 2 (HER2) with HER3 initiates aberrant downstream growth-signaling pathways in tumors. Our objective was to construct bispecific radioimmunoconjugates (bsRICs) that recognize HER2 and HER3 and evaluate their ability to image tumors in athymic mice that express one or both receptors using small-animal SPECT/CT. METHODS bsRICs were constructed by reacting the maleimide-derivatized trastuzumab Fab fragments that bind HER2… CONTINUE READING