Small-angle neutron scattering and contrast variation: a powerful combination for studying biological structures.

  title={Small-angle neutron scattering and contrast variation: a powerful combination for studying biological structures.},
  author={William T. Heller},
  journal={Acta crystallographica. Section D, Biological crystallography},
  volume={66 Pt 11},
The use of small-angle scattering (SAS) in the biological sciences continues to increase, driven as much by the need to study increasingly complex systems that are often resistant to crystallization or are too large for NMR as by the availability of user facilities and advancements in the modelling of biological structures from SAS data. SAS, whether with neutrons (SANS) or X-rays (SAXS), is a structural probe of length scales ranging from 10 to 10,000 Å. When applied to biological complexes in… CONTINUE READING

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