Small and Random Peptides: An Unexplored Reservoir of Potentially Functional Primitive Organocatalysts. The Case of Seryl-Histidine

@article{Wieczorek2017SmallAR,
  title={Small and Random Peptides: An Unexplored Reservoir of Potentially Functional Primitive Organocatalysts. The Case of Seryl-Histidine},
  author={Rafal Wieczorek and Katarzyna P Adamala and T. Gasperi and F. Polticelli and P. Stano},
  journal={Life},
  year={2017},
  volume={7}
}
  • Rafal Wieczorek, Katarzyna P Adamala, +2 authors P. Stano
  • Published 2017
  • Biology, Medicine
  • Life
  • Catalysis is an essential feature of living systems biochemistry, and probably, it played a key role in primordial times, helping to produce more complex molecules from simple ones. However, enzymes, the biocatalysts par excellence, were not available in such an ancient context, and so, instead, small molecule catalysis (organocatalysis) may have occurred. The best candidates for the role of primitive organocatalysts are amino acids and short random peptides, which are believed to have been… CONTINUE READING
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    References

    SHOWING 1-10 OF 143 REFERENCES
    Can an Imidazole Be Formed from an Alanyl-Seryl-Glycine Tripeptide under Possible Prebiotic Conditions?
    • 10
    Formation of RNA Phosphodiester Bond by Histidine‐Containing Dipeptides
    • 36
    • PDF
    Self-replicating amphiphilic beta-sheet peptides.
    • 89
    Glutathione as a prebiotic answer to α-peptide based life.
    • 6
    • PDF
    Short Peptides in Minimalistic Biocatalyst Design
    • 25
    Protease‐Catalyzed Kinetically Controlled Peptide Synthesis
    • 152
    A chiroselective peptide replicator
    • 200
    • PDF
    Common origins of RNA, protein and lipid precursors in a cyanosulfidic protometabolism.
    • 331
    • PDF