Small airway closure and positive end-expiratory pressure in mechanically ventilated patients with chronic obstructive pulmonary disease.

@article{Gurin1997SmallAC,
  title={Small airway closure and positive end-expiratory pressure in mechanically ventilated patients with chronic obstructive pulmonary disease.},
  author={Claude Gu{\'e}rin and St{\'e}phane Lemasson and Roland De Varax and Joseph Milic-Emili and G{\'e}rard Fournier},
  journal={American journal of respiratory and critical care medicine},
  year={1997},
  volume={155 6},
  pages={1949-56}
}
The effects of positive end-expiratory pressure (PEEP) on alveolar recruitment and closing volume were studied in ten supine, sedated, and paralyzed patients with chronic obstructive respiratory disease and acute respiratory failure. We applied PEEP (0, 5, 10, and 15 cm H2O) and constructed inflation static volume-pressure (V-P) curves. In all patients, the static V-P curves obtained at different PEEP levels were superimposed on each other, indicating that with PEEP there was no recruitment of… CONTINUE READING
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