Small-Scale Modeling of Pharmaceutical Powder Compression from Tap Density Testers, to Roller Compactors, and to the Tablet Press Using Big Data

@article{Shi2016SmallScaleMO,
  title={Small-Scale Modeling of Pharmaceutical Powder Compression from Tap Density Testers, to Roller Compactors, and to the Tablet Press Using Big Data},
  author={Zhenqi Shi and Jon L. Hilden},
  journal={Journal of Pharmaceutical Innovation},
  year={2016},
  volume={12},
  pages={41-48}
}
Roller compaction is commonly used in the pharmaceutical industry to improve powder flow and compositional uniformity. The process produces ribbons which are milled into granules. The ribbon solid fraction (SF) can affect both the granule size and the tensile strength of downstream tablets. Roll force, which is directly related to the applied stress on the… CONTINUE READING