Small-Scale Assays for Studying Dissolution of Pharmaceutical Cocrystals for Oral Administration

@article{Box2015SmallScaleAF,
  title={Small-Scale Assays for Studying Dissolution of Pharmaceutical Cocrystals for Oral Administration},
  author={Karl J. Box and John C. Comer and Robert Taylor and Shyam Karki and Rebeca Ruiz and Robert Price and Nikoletta Fotaki},
  journal={AAPS PharmSciTech},
  year={2015},
  volume={17},
  pages={245-251}
}
The purpose of this study was to better understand the dissolution properties and precipitation behavior of pharmaceutical cocrystals of poorly soluble drugs for the potential for oral administration based on a small-scale dissolution assay. Carbamazepine and indomethacin cocrystals with saccharin and nicotinamide as coformers were prepared with the sonic slurry method. Dissolution of the poorly soluble drugs indomethacin and carbamazepine and their cocrystals was studied with a small-scale… CONTINUE READING