Small Regulatory RNAs May Sharpen Spatial Expression Patterns

@article{Levine2007SmallRR,
  title={Small Regulatory RNAs May Sharpen Spatial Expression Patterns },
  author={Erel Levine and Peter T. McHale and Herbert Levine},
  journal={PLoS Computational Biology},
  year={2007},
  volume={3},
  pages={83 - 93}
}
The precise establishment of gene expression patterns is a crucial step in development. Formation of a sharp boundary between high and low spatial expression domains requires a genetic mechanism that exhibits sensitivity, yet is robust to fluctuations, a demand that may not be easily achieved by morphogens alone. Recently, it has been demonstrated that small RNAs (and, in particular, microRNAs) play many roles in embryonic development. Whereas some RNAs are essential for embryogenesis, others… CONTINUE READING
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