Small RNAs derived from lncRNA RNase MRP have gene-silencing activity relevant to human cartilage-hair hypoplasia.

@article{Rogler2014SmallRD,
  title={Small RNAs derived from lncRNA RNase MRP have gene-silencing activity relevant to human cartilage-hair hypoplasia.},
  author={Leslie E. Rogler and Brian Kosmyna and David Moskowitz and Remon S Bebawee and Joseph Rahimzadeh and Katrina M. Kutchko and Alain Laederach and Luigi D Notarangelo and Silvia Giliani and Eric E. Bouhassira and Paul S Frenette and Jayanta Roy-Chowdhury and Charles E. Rogler},
  journal={Human molecular genetics},
  year={2014},
  volume={23 2},
  pages={368-82}
}
Post-transcriptional processing of some long non-coding RNAs (lncRNAs) reveals that they are a source of miRNAs. We show that the 268-nt non-coding RNA component of mitochondrial RNA processing endoribonuclease, (RNase MRP), is the source of at least two short (∼20 nt) RNAs designated RMRP-S1 and RMRP-S2, which function as miRNAs. Point mutations in RNase MRP cause human cartilage-hair hypoplasia (CHH), and several disease-causing mutations map to RMRP-S1 and -S2. SHAPE chemical probing… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 27 extracted citations

Similar Papers

Loading similar papers…