Small RNAs as Guardians of the Genome

  title={Small RNAs as Guardians of the Genome},
  author={Colin D. Malone and Gregory J Hannon},
Transposons populate the landscape of all eukaryotic genomes. Often considered purely genomic parasites, transposons can also benefit their hosts, playing roles in gene regulation and in genome organization and evolution. Peaceful coexistence with mobile elements depends upon adaptive control mechanisms, since unchecked transposon activity can impact long-term fitness and acutely reduce the fertility of progeny. Here, we review the conserved roles played by small RNAs in the adaptation of… CONTINUE READING
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