Small RNA profiling reveals antisense transcription throughout the KSHV genome and novel small RNAs.

@article{Lin2010SmallRP,
  title={Small RNA profiling reveals antisense transcription throughout the KSHV genome and novel small RNAs.},
  author={Yao-Tang Lin and Rodney P Kincaid and Dhivya Arasappan and Scot E. Dowd and Scott P. Hunicke-Smith and Christopher S. Sullivan},
  journal={RNA},
  year={2010},
  volume={16 8},
  pages={1540-58}
}
Kaposi's sarcoma-associated herpesvirus (KSHV) is a human tumor virus that encodes 12 precursor microRNAs (pre-miRNAs) that give rise to 17 different known approximately 22-nucleotide (nt) effector miRNAs. Like all herpesviruses, KSHV has two modes of infection: (1) a latent mode whereby only a subset of viral genes are expressed and (2) a lytic mode during which the full remaining viral genes are expressed. To date, KSHV miRNAs have been mostly identified via analysis of cells that are… CONTINUE READING