Small RNA-mediated quiescence of transposable elements in animals.

  title={Small RNA-mediated quiescence of transposable elements in animals.},
  author={Kuniaki Saito and Mikiko C Siomi},
  journal={Developmental cell},
  volume={19 5},
Transposable elements (TEs) are major components of the intergenic regions of the genome. However, TE transposition has the potential to threaten the reproductive fitness of the organism; therefore, organisms have evolved specialized molecular systems to sense and repress the expression of TEs to stop them from jumping to other genomic loci. Emerging evidence suggests that Argonaute proteins play a critical role in this process, in collaboration with two types of cellular small RNAs: PIWI… CONTINUE READING

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