Small RNA-induced transcriptional gene regulation in mammals mechanisms, therapeutic applications, and scope within the genome.

@article{Green2011SmallRT,
  title={Small RNA-induced transcriptional gene regulation in mammals mechanisms, therapeutic applications, and scope within the genome.},
  author={Victoria A. Green and Marc S Weinberg},
  journal={Progress in molecular biology and translational science},
  year={2011},
  volume={102},
  pages={11-46}
}
Argonaute-bound small RNAs, derived from RNA interference and related pathways, are well-known effectors of posttranscriptional gene silencing (PTGS). Yet, these complexes also play an important role in affecting gene expression at the transcriptional level, either by transcriptional gene silencing (TGS) or activation (TGA). Our current understanding of how small RNAs are able to both activate and suppress transcription is unclear. In this review, we briefly outline the biogenesis of small RNAs… CONTINUE READING

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