Small RNA Modules Confer Different Stabilities and Interact Differently with Multiple Targets

  title={Small RNA Modules Confer Different Stabilities and Interact Differently with Multiple Targets},
  author={Jos{\'e} M Andrade and V{\^a}nia Pobre and Cec{\'i}lia M Arraiano},
  booktitle={PloS one},
Bacterial Hfq-associated small regulatory RNAs (sRNAs) parallel animal microRNAs in their ability to control multiple target mRNAs. The small non-coding MicA RNA represses the expression of several genes, including major outer membrane proteins such as ompA, tsx and ecnB. In this study, we have characterised the RNA determinants involved in the stability of MicA and analysed how they influence the expression of its targets. Site-directed mutagenesis was used to construct MicA mutated forms. The… CONTINUE READING
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