Small Molecules Targeted to a Non-Catalytic “RVxF” Binding Site of Protein Phosphatase-1 Inhibit HIV-1

@inproceedings{Ammosova2012SmallMT,
  title={Small Molecules Targeted to a Non-Catalytic “RVxF” Binding Site of Protein Phosphatase-1 Inhibit HIV-1},
  author={Tatiana Ammosova and Maxim O Platonov and Venkat S. R. K. Yedavalli and Yuri Obukhov and Victor R Gordeuk and K T Jeang and Dmytro Kovalskyy and Sergei Nekhai},
  booktitle={PloS one},
  year={2012}
}
HIV-1 Tat protein recruits host cell factors including CDK9/cyclin T1 to HIV-1 TAR RNA and thereby induces HIV-1 transcription. An interaction with host Ser/Thr protein phosphatase-1 (PP1) is critical for this function of Tat. PP1 binds to a Tat sequence, Q(35)VCF(38), which resembles the PP1-binding "RVxF" motif present on PP1-binding regulatory subunits. We showed that expression of PP1 binding peptide, a central domain of Nuclear Inhibitor of PP1, disrupted the interaction of HIV-1 Tat with… CONTINUE READING

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