Small Molecule Therapeutics The Tyrphostin NT 157 Suppresses Insulin Receptor Substrates and Augments Therapeutic Response of Prostate Cancer

@inproceedings{Ibuki2014SmallMT,
  title={Small Molecule Therapeutics The Tyrphostin NT 157 Suppresses Insulin Receptor Substrates and Augments Therapeutic Response of Prostate Cancer},
  author={Naokazu Ibuki and Mazyar Ghaffari and Hadas Reuveni and Mitali Pandey and Ladan Fazli and Haruhito Azuma and Martin E. Gleave and Alexander Levitzki and Michael E. Cox},
  year={2014}
}
Insulin-like growth factor (IGF) signaling is associated with castrate-resistant prostate cancer (CRPC) progression. Insulin receptor substrates 1 and 2 (IRS1/2) mediate mitogenic and antiapoptotic signaling from IGF1 receptor (IGF1R), insulin receptor, and other oncoproteins. This study demonstrates that IRS1/2 expression is increased in prostate cancer, and persists in CRPC. Furthermore, this study assesses the anticancer activity of NT157, a small molecule tyrphostin targeting IRS proteins… CONTINUE READING

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