Small Molecule Therapeutics RadiationProtectionof theGastrointestinal Tract andGrowth Inhibition of Prostate Cancer Xenografts by a Single Compound

@inproceedings{Alexeev2014SmallMT,
  title={Small Molecule Therapeutics RadiationProtectionof theGastrointestinal Tract andGrowth Inhibition of Prostate Cancer Xenografts by a Single Compound},
  author={Vitali Alexeev and Elizabeth Lash and April Aguillard and Laura Corsini and Avi Bitterman and Keith Ward and Adam Dicker and Alban J. Linnenbach and Ulrich Rodeck},
  year={2014}
}
Normal tissue toxicity markedly reduces the therapeutic index of genotoxic anticancer agents, including ionizing radiation.Countermeasures against tissuedamage causedby radiation are limitedby their potential to also protect malignant cells and tissues. Here, we tested a panel of signal transduction modifiers for selective radioprotection of normal but not tumor tissues. These included three inhibitors of GSK3 (LiCl, SB216763, and SB415286) and two inhibitors of NF-kB (ethyl pyruvate and RTA… CONTINUE READING
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