Small Molecule Therapeutics Pharmacologic Inhibition of MEK Signaling Prevents Growth of Canine Hemangiosarcoma

Abstract

Angiosarcoma is a rare neoplasm of endothelial origin that has limited treatment options and poor five-year survival. As amodel for human angiosarcoma, we studied primary cells and tumorgrafts derived from canine hemangiosarcoma (HSA), which is also an endothelial malignancy with similar presentation and histology. Primary cells isolated from HSA showed… (More)

Topics

8 Figures and Tables

Cite this paper

@inproceedings{Andersen2013SmallMT, title={Small Molecule Therapeutics Pharmacologic Inhibition of MEK Signaling Prevents Growth of Canine Hemangiosarcoma}, author={Nicholas J Andersen and Brian J. Nickoloff and Karl J. Dykema and Elissa A. Boguslawski and Roman I. Krivochenitser and Michelle J. Dawes and Laurence H. Baker and D. Gnanaraj Thomas and Debra A. Kamstock and Barbara E. Kitchell and Kyle A. Furge and Nicholas S. Duesbery}, year={2013} }