Small Molecule Therapeutics MTI-101 ( Cyclized HYD 1 ) Binds a CD 44 Containing Complex and Induces Necrotic Cell Death in Multiple Myeloma

Abstract

Our laboratory recently reported that treatment with the D-amino acid containing peptide HYD1 induces necrotic cell death in multiple myeloma cell lines. Because of the intriguing biological activity and promising in vivo activity of HYD1, we pursued strategies for increasing the therapeutic efficacy of the linear peptide. These efforts led to a cyclized… (More)

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