Small Molecule Therapeutics AZD2014, an Inhibitor of mTORC1 and mTORC2, Is Highly Effective in ER Breast Cancer When Administered Using Intermittent or Continuous Schedules


mTOR is an atypical serine threonine kinase involved in regulating major cellular functions, such as nutrients sensing, growth, and proliferation. mTOR is part of the multiprotein complexes mTORC1 and mTORC2, which have been shown to play critical yet functionally distinct roles in the regulation of cellular processes. Current clinical mTOR inhibitors only… (More)


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