Small-Molecule Targeting of E3 Ligase Adaptor SPOP in Kidney Cancer.


In the cytoplasm of virtually all clear-cell renal cell carcinoma (ccRCC), speckle-type POZ protein (SPOP) is overexpressed and misallocated, which may induce proliferation and promote kidney tumorigenesis. In normal cells, however, SPOP is located in the nucleus and induces apoptosis. Here we show that a structure-based design and subsequent hit… (More)
DOI: 10.1016/j.ccell.2016.08.003

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