Small-Molecule Suppressors of Cytokine-Induced beta-Cell Apoptosis.

@article{Chou2010SmallMoleculeSO,
  title={Small-Molecule Suppressors of Cytokine-Induced beta-Cell Apoptosis.},
  author={Danny Hung-Chieh Chou and Nicole E. Bodycombe and Hyman A. Carrinski and Timothy A. Lewis and Paul A. Clemons and Stuart L. Schreiber and Bridget K Wagner},
  journal={ACS chemical biology},
  year={2010},
  volume={5 8},
  pages={
          729-34
        }
}
Pancreatic beta-cell apoptosis is a critical event during the development of type-1 diabetes. The identification of small molecules capable of preventing cytokine-induced apoptosis could lead to avenues for therapeutic intervention. We developed a set of phenotypic cell-based assays designed to identify such small-molecule suppressors. Rat INS-1E cells were simultaneously treated with a cocktail of inflammatory cytokines and a collection of 2,240 diverse small molecules and screened using an… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 14 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 25 REFERENCES

Similar Papers

Loading similar papers…