Small Molecule Inhibitors of the Hedgehog Pathway in the Treatment of Basal Cell Carcinoma of the Skin.

@article{Danhof2018SmallMI,
  title={Small Molecule Inhibitors of the Hedgehog Pathway in the Treatment of Basal Cell Carcinoma of the Skin.},
  author={Rebecca S Danhof and Karl D. Lewis and Mariah R Brown},
  journal={American journal of clinical dermatology},
  year={2018},
  volume={19 2},
  pages={
          195-207
        }
}
Basal cell carcinoma (BCC) is the most common type of skin cancer, with rising incidence rates primarily attributed to an aging population and ultraviolet radiation exposure. While the majority of BCCs are localized and respond to standard therapies, a very small minority of these tumors become locally destructive or metastasize. These advanced BCCs may not be amenable to localized treatment with surgery and/or radiation therapy. Most BCCs result from mutations in key receptors in the Hedgehog… CONTINUE READING