Small-Molecule Inhibitors Targeting DNA Repair and DNA Repair Deficiency in Research and Cancer Therapy.

@article{Hengel2017SmallMoleculeIT,
  title={Small-Molecule Inhibitors Targeting DNA Repair and DNA Repair Deficiency in Research and Cancer Therapy.},
  author={Sarah R. Hengel and M. Ashley Spies and Maria Spies},
  journal={Cell chemical biology},
  year={2017},
  volume={24 9},
  pages={
          1101-1119
        }
}
To maintain stable genomes and to avoid cancer and aging, cells need to repair a multitude of deleterious DNA lesions, which arise constantly in every cell. Processes that support genome integrity in normal cells, however, allow cancer cells to develop resistance to radiation and DNA-damaging chemotherapeutics. Chemical inhibition of the key DNA repair proteins and pharmacologically induced synthetic lethality have become instrumental in both dissecting the complex DNA repair networks and as… CONTINUE READING
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